Structural ensemble of an intrinsically disordered polypeptide.

  title={Structural ensemble of an intrinsically disordered polypeptide.},
  author={Jeetain Mittal and Tae Hyeon Yoo and George Georgiou and Thomas M Truskett},
  journal={The journal of physical chemistry. B},
  volume={117 1},
Intrinsically disordered proteins (IDPs), which play key roles in cell signaling and regulation, do not display specific tertiary structure when isolated in solution. Instead, they dynamically explore an ensemble of unfolded configurations, adopting more stable, ordered structures only after binding to their ligands. Whether ligands induce IDP structural changes upon binding or simply bind to pre-existing conformers that are populated within the IDP's structural ensemble is not well understood… CONTINUE READING

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