• Chemistry, Medicine
  • Published in
    Rapid communications in mass…
    2014
  • DOI:10.1002/rcm.6970

Structural elucidation of stress degradation products of ampicillin sodium by liquid chromatography/hybrid triple quadrupole linear ion trap mass spectrometry and liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry.

@article{Li2014StructuralEO,
  title={Structural elucidation of stress degradation products of ampicillin sodium by liquid chromatography/hybrid triple quadrupole linear ion trap mass spectrometry and liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry.},
  author={Tao Li and Xuanlin Xu and Shan Fu and Juan Zhang and Kerong Zhang and Shuang Wang and Minmin Zhao and Weijing Ding and Qiao Wang},
  journal={Rapid communications in mass spectrometry : RCM},
  year={2014},
  volume={28 17},
  pages={
          1929-36
        }
}
RATIONALE Clinical adverse reactions to ampicillin sodium are closely related to its impurities and degradation products. Several unknown degradation products have been detected in the degradation samples of ampicillin sodium. Therefore, a sensitive and accurate method is required to rapidly identify unknown degradation products. METHODS Ampicillin sodium was subjected to forced degradation under hydrolytic (acidic and alkaline), hot, photolytic, and humid stress conditions. A combination of… CONTINUE READING
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