Structural elucidation of drug metabolites by triple-quadrupole mass spectrometry

@article{Perchalski1982StructuralEO,
  title={Structural elucidation of drug metabolites by triple-quadrupole mass spectrometry},
  author={Robert J. Perchalski and Richard A. Yost and B. J. Wilder},
  journal={Analytical Chemistry},
  year={1982},
  volume={54},
  pages={1466-1471}
}
Diagnostic fragmentation filtering for the discovery of new chaetoglobosins and cytochalasins.
TLDR
DFF has proved useful in the identification of new natural products and allowing for their partial characterization without the need for isolation, and is an effective LC/MS data analysis approach for rapidly identifying entire classes of compounds from complex mixtures. Expand
Stable isotope labeling - dispersive solid phase extraction - liquid chromatography - tandem mass spectrometry for quantitative analysis of transsulfuration pathway thiols in human serum.
  • Ya-lan Wang, Quan-Fei Zhu, +8 authors Y. Feng
  • Chemistry, Medicine
  • Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • 2018
TLDR
The findings indicated that significantly changed thiols occurring in the transsulfuration pathway in type 2 diabetes mellitus patients and breast cancer patients might serve as the indicator for the diagnosis of T2DM and BC. Expand
Application of C8 liquid chromatography-tandem mass spectrometry for the analysis of enniatins and bassianolides.
TLDR
A semi-targeted LC-MS/MS approach utilizing reversed-phase C8 UHPLC column chromatography that combines both product ion and neutral loss filtering was developed to detect enniatins and structurally-related compounds in a sample. Expand
New Tandem Mass Spectrometric Methods of Structure and Sequence Elucidation of Synthetic and Tryptic Peptides
New Tandem Mass Spectrometric Methods of Structure and Sequence Elucidation of Synthetic and Tryptic Peptides
Ion Dissociation Methods in Proteomics
This article serves as a review of polypeptide ion dissociation methods in the context of mass spectrometry (MS)-based proteomic analysis. Given the many tandem mass spectrometry (MS/MS) instrumentExpand
Multiple reaction monitoring (MRM) of plasma proteins in cardiovascular proteomics.
TLDR
Although it has been traditionally used for quantification of small molecules in clinical chemistry, MRM is now emerging as an alternative to traditional immunoassays for candidate protein biomarker validation. Expand
Identification of Drug Metabolites
The elucidation of chemical structures of drug metabolites is a key endeavor in the research on new drugs. The data can be useful both in the early drug design processes and later in the drugExpand
Identification of phase I metabolites of cardiovascular and anti-ulcer drugs in surface water samples with liquid-chromatography-mass spectrometry methods.
In our study we have identified phase I metabolites of cardiovascular and anti-ulcer agents with the application of predictive multiple reaction monitoring (pMRM) methods withExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 15 REFERENCES
Mass spectrometry of quaternary ammoniohexanoates: Intermolecular alkyl transfer during field desorption
Intermolecular alkyl transfer occurs during field desorption of quaternary ammoniohexanoates, resulting in mass spectra containing structurally diagnostic adduct ions. Methyl, ethyl and propyl groupsExpand
Simultaneous determination of the anticonvulsants, cinromide (3-bromo-n-ethylcinnamamide), 3-bromocinnamamide, and carbamazepine in plasma by high-performance liquid chromatography.
TLDR
A high-performance liquid chromatographic method is described for monitoring plasma concentrations of cinromide and its de-ethylated metabolite, which may have some anticonvulsant effect and can be analyzed simultaneously by buffering the mobile phase and adding an ion-pairing reagent. Expand
Triple Quadrupole Mass Spectrometry
Beitrag zum Mechanismus der stossinduzierten Fragmentierungen von quaternären Stickstoffverbindungen. 2. Mitteilung über stossinduzierte Fragmentierungen von felddesorbierten Kationen
Mechanistic studies on the collision-induced fragmentations of quaternary ammonium ions The collision-induced fragmentation behaviour of field desorbed quarternary ammonium ions has beenExpand
Mass analysed collisional activation mass spectra of organic salt cations produced by field desorption linked magnetic and electric field scanning
The collisional activation mass spectra of some organic salt cations produced by field desorption are reported. The principal fragmentations of these ions are discussed. The collisional activationExpand
Collisional activation spectra of quarternary ammonium cations produced by field desorption
Collisional activation spectra of quarternary ammonium cations produced by field desorption are reported. The principal fragmentation pathways of these ions are discussed. Furthermore, it isExpand
Field desorption mass spectrometry of quaternary ammonium salts: Cluster ion formation
The field desorption mass spectra of salts such as quaternary ammonium and carbenium salts with organic cations in addition to high cation intensities show signals for cluster ions composed of theExpand
...
1
2
...