Structural elements near the C-terminus are responsible for changes in nicotinic receptor gating kinetics following patch excision.

@article{Akk2000StructuralEN,
  title={Structural elements near the C-terminus are responsible for changes in nicotinic receptor gating kinetics following patch excision.},
  author={Gustav Akk and Joe Henry Steinbach},
  journal={The Journal of physiology},
  year={2000},
  volume={527 Pt 3},
  pages={405-17}
}
We have studied the effect of patch excision on the gating kinetics of muscle nicotinic acetylcholine receptors transiently expressed in HEK 293 cells. The experiments were performed on embryonic and adult wild-type, and several mutated, receptors using acetylcholine, carbamylcholine and tetramethylammonium as agonists. We show that patch excision of cell-attached patches into the inside-out configuration led to a reduction of mean open duration in receptors containing a gamma-subunit… CONTINUE READING

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