Structural dynamics of the Streptomyces lividans K+ channel (SKC1): oligomeric stoichiometry and stability.

@article{Cortes1997StructuralDO,
  title={Structural dynamics of the Streptomyces lividans K+ channel (SKC1): oligomeric stoichiometry and stability.},
  author={D. Marien Cortes and Eduardo Perozo},
  journal={Biochemistry},
  year={1997},
  volume={36 33},
  pages={10343-52}
}
SKC1, a 160-residue potassium channel with two putative transmembrane (TM) segments was recently identified from Streptomyces lividans. Its high levels of expression, small size, and ease of purification make SKC1 an ideal candidate for high-resolution structural studies. We have initiated the structural characterization of this channel by assessing its oligomeric behavior, stability in detergent, general hydrodynamic properties, and preliminary secondary structure content. SKC1 was readily… CONTINUE READING