Structural dynamics of the S4 voltage-sensor helix in lipid bilayers lacking phosphate groups.

Abstract

Voltage-dependent K(+) (Kv) channels require lipid phosphates for functioning. The S4 helix, which carries the gating charges in the voltage-sensing domain (VSD), inserts into membranes while being stabilized by a protein-lipid interface in which lipid phosphates play an essential role. To examine the physical basis of the protein-lipid interface in the… (More)
DOI: 10.1021/jp2001964

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