Structural dynamics of synapses in vivo correlate with functional changes during experience-dependent plasticity in visual cortex.

@article{Tropea2010StructuralDO,
  title={Structural dynamics of synapses in vivo correlate with functional changes during experience-dependent plasticity in visual cortex.},
  author={Daniela Tropea and Ania K Majewska and Rodrigo Garc{\'i}a and Mriganka Sur},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 33},
  pages={11086-95}
}
The impact of activity on neuronal circuitry is complex, involving both functional and structural changes whose interaction is largely unknown. We have used optical imaging of mouse visual cortex responses and two-photon imaging of superficial layer spines on layer 5 neurons to monitor network function and synaptic structural dynamics in the mouse visual cortex in vivo. Total lack of vision due to dark-rearing from birth dampens visual responses and shifts spine dynamics and morphologies toward… CONTINUE READING
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