Structural dynamics of bacterial translation initiation factor IF2.

  title={Structural dynamics of bacterial translation initiation factor IF2.},
  author={Hans L J Wienk and Evgeny Tishchenko and Riccardo Belardinelli and Simona Tomaselli and Ramachandra Dongre and Roberto Spurio and Gert E. Folkers and Claudio O. Gualerzi and Rolf Boelens},
  journal={The Journal of biological chemistry},
  volume={287 14},
Bacterial translation initiation factor IF2 promotes ribosomal subunit association, recruitment, and binding of fMet-tRNA to the ribosomal P-site and initiation dipeptide formation. Here, we present the solution structures of GDP-bound and apo-IF2-G2 of Bacillus stearothermophilus and provide evidence that this isolated domain binds the 50 S ribosomal subunit and hydrolyzes GTP. Differences between the free and GDP-bound structures of IF2-G2 suggest that domain reorganization within the G2-G3… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 10 extracted citations


Publications referenced by this paper.

hp://w w w D ow nladed from Structural dynamics of bacterial IF2

  • H. Song, M. R. Parsons, S. Rowsell, G. Leonard, S. E. Phillips
  • J. Mol. Biol
  • 1999

Similar Papers

Loading similar papers…