Structural diversity of angiotensin-converting enzyme: Insights from structure-activity comparisons of two Drosophila enzymes

@inproceedings{Bingham2006StructuralDO,
  title={Structural diversity of angiotensin-converting enzyme: Insights from structure-activity comparisons of two Drosophila enzymes},
  author={Richard J Bingham and Vincent Dive and Simon E V Phillips and Alan Shirras and R Elwyn Isaac},
  year={2006}
}
The crystal structure of a Drosophila angiotensin-converting enzyme (ANCE) has recently been solved, revealing features important for the binding of ACE inhibitors and allowing molecular comparisons with the structure of human testicular angiotensin-converting enzyme (tACE). ACER is a second Drosophila ACE that displays both common and distinctive properties. Here we report further functional differences between ANCE and ACER and have constructed a homology model of ACER to help explain these… CONTINUE READING