Structural diversity of PDZ-lipid interactions.

  title={Structural diversity of PDZ-lipid interactions.},
  author={Rodrigo Gallardo and Ylva Ivarsson and Joost Schymkowitz and Frederic Rousseau and Pascale Zimmermann},
  journal={Chembiochem : a European journal of chemical biology},
  volume={11 4},
PDZ domains are globular protein modules that are over-and-above appreciated for their interaction with short peptide motifs found in the cytosolic tail of membrane receptors, channels, and adhesion molecules. These domains predominate in scaffold molecules that control the assembly and the location of large signaling complexes. Studies have now emerged showing that PDZ domains can also interact with membrane lipids, and in particular with phosphoinositides. Phosphoinositides control various… CONTINUE READING