Structural diversity and defensive properties of diterpenoid alkaloids

  title={Structural diversity and defensive properties of diterpenoid alkaloids},
  author={Mat{\'i}as Reina and Azucena Gonz{\'a}lez-Coloma},
  journal={Phytochemistry Reviews},
Diterpenoid alkaloids are compounds of pharmacological interest. Forty four C19 norditerpenoid (NDAs) and 23 C20 diterpenoid (DAs) alkaloids isolated from Aconitum, Delphinium and Consolida species were tested for their insecticidal effects (antifeedant and toxic) on Spodoptera littoralis and Leptinotarsa decemlineata, their cytotoxicity on tumoral cell lines with several multidrug resistance mechanisms, and their antiparasitic effects against Trypanososma cruzi and Leishmania infantum. Overall… 
Diterpenoid Alkaloids from Two Aconitum Species with Antifeedant Activity against Spodoptera exigua.
Twenty-five diterpenoid alkaloids were isolated from the roots of two Aconitum species and chasmanthinine (19) showed highly potent antifeedant activity with an effective concentration for 50% feeding reduction (EC50) at 0.07 mg/cm2.
Chemistry and biological activities of hetisine-type diterpenoid alkaloids
Parmacological studies have revealed a wide range of pharmacological actions for hetisine-type DAs, including antiarrhythmic, antitumor, antimicrobial and insecticidal activities, as well as effects on peripheral vasculature, which are closely related to their chemical structures.
C18-diterpenoid alkaloids in tribe Delphineae (Ranunculaceae): phytochemistry, chemotaxonomy, and bioactivities
The Delphineae plant C18-DAs can serve as good chemical molecular markers in the taxonomic treatment of plants within this tribe, especially in the infrageneric division.
The C19-diterpenoid alkaloids.
Bioactive heterocyclic alkaloids with diterpene structure isolated from traditional Chinese medicines.
The Cytotoxicity and Insecticidal Activity of Extracts from Delphinium formosum Boiss. & Huet
The cytotoxic extract of D. formosum was examined for its adulticidal and larvicidal activity against the yellow fever, dengue fevers and Zika virus vector Aedes aegypti L.
Diterpenoid Alkaloids from Aconitum soongaricum var. pubescens
One new diterpenoid alkaloid was isolated from the roots of Aconitum soongaricum var.


Antifeedant C20 Diterpene Alkaloids
The results support the plant protective role of C20 diterpenoid alkaloids and open a new field for parasite control strategies, as well as supporting the antifeedant effects of test compounds, which were structure‐ and species‐dependent.
Structural Diversity and Defensive Properties of Norditerpenoid Alkaloids
The selective cytotoxic effects of some structures indicate that they can act on biological targets other than neuroreceptors in Spodoptera littoralis and Leptinotarsa decemlineata.
Antifeedant Delphinium Diterpenoid Alkaloids. Structure-Activity Relationships.
Cardiopetamine showed little antifungal action against several species of plant pathogens and did not have any mutagenic effects on Salmonella typhimurium by means of the Ames test.
In vitro activity of C20-diterpenoid alkaloid derivatives in promastigotes and intracellular amastigotes of Leishmania infantum.
Larkspur poisoning: toxicology and alkaloid structure-activity relationships
Antiplatelet aggregation activity of diterpene alkaloids from Spiraea japonica.
In vitro Cytotoxicity of Norditerpenoid Alkaloids
The results suggest that the effects of these compounds could be related to the inhibition of ATP production and compared the cell viability by means of theMTT and the acid phosphatase (AP) methods.
Antifeedant Effects of Some Novel Terpenoids on Chrysomelidae Beetles: Comparisons with Alkaloids on an Alkaloid-Adapted and Nonadapted Species
The wide differences in antifeedant sensitivities among these and other chrysomelids to a suite of ligand-gated ion channel antagonists implicate a common protein neuroreceptor type with extraordinary heterogeneity in beetle taste.
Diterpenoid Alkaloid Derivatives as Potential Chemotherapeutic Agents in American Trypanosomiasis
Results suggest that these diterpenoid alkaloids are structural leads of clinically active compounds against T. cruzi and probably other members of the Trypanosomatidae.
Aconitum sp. alkaloids: the modulation of voltage-dependent Na+ channels, toxicity and antinociceptive properties.