Structural disorder serves as a weak signal for intracellular protein degradation.

@article{Tompa2008StructuralDS,
  title={Structural disorder serves as a weak signal for intracellular protein degradation.},
  author={Peter Tompa and Jaime Prilusky and Israel Silman and Joel L. Sussman},
  journal={Proteins},
  year={2008},
  volume={71 2},
  pages={903-9}
}
Targeted turnover of proteins is a key element in the regulation of practically all basic cellular processes. The underlying physicochemical and/or sequential signals, however, are not fully understood. This issue is particularly pertinent in light of the recent recognition that intrinsically unstructured/disordered proteins, common in eukaryotic cells, are extremely susceptible to proteolytic degradation in vitro. The in vivo half-lives of proteins were determined recently in a high-throughput… CONTINUE READING