Structural differences between the repertoires of mouse and human germline genes and their evolutionary implications

@article{Almagro1998StructuralDB,
  title={Structural differences between the repertoires of mouse and human germline genes and their evolutionary implications},
  author={J. Almagro and Ismael Mateos Hern{\'a}ndez and Maria del Carmen Ram{\'i}rez and Enrique Vargas-Madrazo},
  journal={Immunogenetics},
  year={1998},
  volume={47},
  pages={355-363}
}
 Although human and mouse antibodies are similar when one considers their diversification strategies, they differ in the extent to which kappa and lambda light chains are present in their respective variable light chain repertoires. While the Igk-V germline genes are preponderant in mice (95% or more), they comprise only 60% in humans. This may account for differences in the structural repertoire encoded in the Igk-V germline genes of these species. However, this subject has not been properly… CONTINUE READING

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