Structural differences between Pb2+- and Ca2+-binding sites in proteins: implications with respect to toxicity.

@article{Kirberger2008StructuralDB,
  title={Structural differences between Pb2+- and Ca2+-binding sites in proteins: implications with respect to toxicity.},
  author={Michael Patrick Kirberger and Jenny J. Yang},
  journal={Journal of inorganic biochemistry},
  year={2008},
  volume={102 10},
  pages={1901-9}
}
Pb(2+) is known to displace physiologically-relevant metal ions in proteins. To investigate potential relationships between Pb(2+)/protein complexes and toxicity, data from the protein data bank were analyzed to compare structural properties of Pb(2+)- and Ca(2+)-binding sites. Results of this analysis reveal that the majority of Pb(2+) sites (77.1%) involve 2-5 binding ligands, compared with 6+/-2 for non-EF-Hand and 7+/-1 for EF-Hand Ca(2+)-binding sites. The mean net negative charge by site… CONTINUE READING