Structural development of synthetic retinoids and thalidomide-related molecules

@article{Hashimoto2003StructuralDO,
  title={Structural development of synthetic retinoids and thalidomide-related molecules},
  author={Y. Hashimoto},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2003},
  volume={52},
  pages={16-23}
}
  • Y. Hashimoto
  • Published 2003
  • Biology, Medicine
  • Cancer Chemotherapy and Pharmacology
The full-scale commercial appearance of antibiotics in the 1950s caused a shift in the nature of lethal diseases from infectious and acute to noninfectious and chronic. In this situation, biological response modifiers (BRMs), which are not based on selective toxicity, could be expected to be useful. Several types of BRM exist, including retinoids, which act directly on cells at the level of gene expression, and thalidomide and related molecules, which modulate the production of various… Expand
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