Structural determination of the vasoactive intestinal peptide by two‐dimensional 1H‐nmr spectroscopy

  title={Structural determination of the vasoactive intestinal peptide by two‐dimensional 1H‐nmr spectroscopy},
  author={Y. Theriault and Y. Boulancer and S. St.-Pierre},
  • Y. Theriault, Y. Boulancer, S. St.-Pierre
  • Published 1991
  • Chemistry, Medicine
  • Biopolymers
  • The structure of the vasoactive intestinal peptide 1–28 in 40% 2,2,2‐trifluoroethanol was investigated by two‐dimensional 1H‐nmr spectroscopy. All 1H resonances, except the γ, δ, and ε protons of the lysine residues, could be sequentially assigned. Numerous intraresidual as well as short‐range interresidual nuclear Overhauser effect spectroscopy connectivities were observed. Using a variable‐target function minimization, a molecular model consisting of two helical stretches involving residues 7… CONTINUE READING
    37 Citations

    Topics from this paper.

    Conformational study of vasoactive intestinal peptide by computational methods.
    • 21
    Enzymatic synthesis of vasoactive intestinal peptide analogs by transglutaminase.
    • 9
    Novel glycosylated VIP analogs: synthesis, biological activity, and metabolic stability
    • D. Dangoor, B. Biondi, +4 authors R. Rocchi
    • Chemistry, Medicine
    • Journal of peptide science : an official publication of the European Peptide Society
    • 2008
    • 19
    Molecular dynamics (MD) simulations of VIP and PACAP27
    • 8
    Solution Structure Comparison of the VIP/PACAP Family of Peptides by NMR Spectroscopy
    • 21


    The structure of melittin. A 1H-NMR study in methanol.
    • 292
    Conformational Analysis of Vasoactive Intestinal Peptide and Related Fragments a
    • 23
    Conformation of glucagon in a lipid-water interphase by 1H nuclear magnetic resonance.
    • 305