Structural determination of the principal byproduct of the lithium-ammonia reduction method of methamphetamine manufacture.

  title={Structural determination of the principal byproduct of the lithium-ammonia reduction method of methamphetamine manufacture.},
  author={Eric C. Person and Jennifer A. Meyer and James R. Vyvyan},
  journal={Journal of forensic sciences},
  volume={50 1},
One common method of illicit methamphetamine manufacture utilizes an alkali metal, typically lithium, and liquid ammonia to chemically reduce ephedrine or pseudoephedrine to form methamphetamine. This method is often referred to as the lithium-ammonia reduction method or the Birch reduction method. While the hydroxyl group of ephedrine is more reactive than the aromatic ring, excess alkali metal and the presence of a proton source allow the formation of a cyclohexadiene byproduct not found in… 

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