Structural determinants within the subunit protein of Ty1 virus-like particles.

@article{MartinRendon1996StructuralDW,
  title={Structural determinants within the subunit protein of Ty1 virus-like particles.},
  author={Enca Martin-Rendon and Gemma Marfany and Sean Wilson and David J. P. Ferguson and Susan M. Kingsman and Alan J. Kingsman},
  journal={Molecular microbiology},
  year={1996},
  volume={22 4},
  pages={667-79}
}
The Ty virus-like particles (VLPs) are functionally analogous to retroviral particles. They package the enzymes and the RNA necessary for retrotransposition, and mediate the integration of the reverse-transcription product into the genome of the host cell. Here we map three structural determinants of particle assembly in the subunit protein. We have also identified key residues in these regions that seem to be involved in subunit interaction and particle morphology. In particular, two point… CONTINUE READING