Structural determinants of the transient receptor potential 1 (TRPV1) channel activation by phospholipid analogs.

Abstract

The transient receptor potential vanilloid 1 (TRPV1) ion channel is a polymodal protein that responds to various stimuli, including capsaicin (the pungent compound found in chili peppers), extracellular acid, and basic intracellular pH, temperatures close to 42 °C, and several lipids. Lysophosphatidic acid (LPA), an endogenous lipid widely associated with… (More)
DOI: 10.1074/jbc.M114.572503

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