Structural determinants of the supramolecular organization of G protein-coupled receptors in bilayers.

@article{Periole2012StructuralDO,
  title={Structural determinants of the supramolecular organization of G protein-coupled receptors in bilayers.},
  author={Xavier Periole and Adam M Knepp and Thomas P. Sakmar and S J Marrink and Thomas Huber},
  journal={Journal of the American Chemical Society},
  year={2012},
  volume={134 26},
  pages={
          10959-65
        }
}
The G protein-coupled receptor (GPCR) rhodopsin self-assembles into supramolecular structures in native bilayers, but the structural determinants of receptor oligomerization are not known. We carried out multiple self-assembly coarse-grained molecular dynamics (CGMD) simulations of model membranes containing up to 64 molecules of the visual receptor rhodopsin over time scales reaching 100 μs. The simulations show strong preferential interaction modes between receptors. Two primary modes of… CONTINUE READING

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