Structural determinants of the interaction between the Haemophilus influenzae Hap autotransporter and fibronectin.

@article{Spahich2014StructuralDO,
  title={Structural determinants of the interaction between the Haemophilus influenzae Hap autotransporter and fibronectin.},
  author={Nicole A. Spahich and Roma Kenjale and Jessica R. McCann and Guoyu Meng and Tomoo Ohashi and Harold P Erickson and Joseph W. St. Geme},
  journal={Microbiology},
  year={2014},
  volume={160 Pt 6},
  pages={1182-90}
}
Haemophilus influenzae is a Gram-negative cocco-bacillus that initiates infection by colonizing the upper respiratory tract. Hap is an H. influenzae serine protease autotransporter protein that mediates adherence, invasion and microcolony formation in assays with human epithelial cells and is presumed to facilitate the process of colonization. Additionally, Hap mediates adherence to fibronectin, laminin and collagen IV, extracellular matrix (ECM) proteins that are present in the respiratory… CONTINUE READING

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