Structural determinants of skeletal muscle ryanodine receptor gating.

@article{Ramachandran2013StructuralDO,
  title={Structural determinants of skeletal muscle ryanodine receptor gating.},
  author={Srinivas Ramachandran and Asima Chakraborty and Le Xu and Yingwu Mei and Montserrat Sams{\'o} and Nikolay V. Dokholyan and Gerhard Meissner},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 9},
  pages={
          6154-65
        }
}
Ryanodine receptor type 1 (RyR1) releases Ca(2+) from intracellular stores upon nerve impulse to trigger skeletal muscle contraction. Effector binding at the cytoplasmic domain tightly controls gating of the pore domain of RyR1 to release Ca(2+). However, the molecular mechanism that links effector binding to channel gating is unknown due to lack of structural data. Here, we used a combination of computational and electrophysiological methods and cryo-EM densities to generate structural models… CONTINUE READING

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