Structural determinants of protein evolution are context-sensitive at the residue level.

  title={Structural determinants of protein evolution are context-sensitive at the residue level.},
  author={Eric A. Franzosa and Yu Xia},
  journal={Molecular biology and evolution},
  volume={26 10},
Structural properties of a protein residue's microenvironment have long been implicated as agents of selective constraint. Although these properties are inherently quantitative, structure-based studies of protein evolution tend to rely upon coarse distinctions between "surface" and "buried" residues and between "interfacial" and "noninterfacial" residues. Using homology-mapped yeast protein structures, we explore the relationships between residue evolution and continuous structural properties… CONTINUE READING
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