Structural determinants of polymerase fidelity and nucleotide discrimination in mammalian DNA pol ß

@inproceedings{Maitra2003StructuralDO,
  title={Structural determinants of polymerase fidelity and nucleotide discrimination in mammalian DNA pol {\ss}},
  author={Mausumi Maitra and Shu-xia Li and Elena Curti and Joachim Jaeger},
  year={2003}
}
DNA polymerase ß mutator mutants Pol ß is one of the smallest eukaryotic polymerases. It is a simple, well-characterised system to study the correlation between polymerase structure and fidelity of DNA synthesis. Polß plays a crucial role in base excision repair (BER) as it removes 5’-deoxyribose phosphate and fills in short lesions in DNA (short patch synthesis). Furthermore, polß is implicated in nucleotide excision repair. There is also evidence to suggest a meiotic function for polß.