Structural determinants of phosphatidylinositol 4,5-bisphosphate (PIP2) regulation of BK channel activity through the RCK1 Ca2+ coordination site.

@article{Tang2014StructuralDO,
  title={Structural determinants of phosphatidylinositol 4,5-bisphosphate (PIP2) regulation of BK channel activity through the RCK1 Ca2+ coordination site.},
  author={Qiong-yao Tang and Zhe Zhang and Xuan-Yu Meng and M. C. Cui and Diomedes E. Logothetis},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 27},
  pages={18860-72}
}
Big or high conductance potassium (BK) channels are activated by voltage and intracellular calcium (Ca(2+)). Phosphatidylinositol 4,5-bisphosphate (PIP2), a ubiquitous modulator of ion channel activity, has been reported to enhance Ca(2+)-driven gating of BK channels, but a molecular understanding of this interplay or even of the PIP2 regulation of this channel's activity remains elusive. Here, we identify structural determinants in the KDRDD loop (which follows the αA helix in the RCK1 domain… CONTINUE READING
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