Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2.

@article{Schmiedeberg2007StructuralDO,
  title={Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2.},
  author={Kristin Schmiedeberg and Elena Shirokova and H Weber and Boris Schilling and Wolfgang Meyerhof and Dietmar Krautwurst},
  journal={Journal of structural biology},
  year={2007},
  volume={159 3},
  pages={400-12}
}
An interaction of odorants with olfactory receptors is thought to be the initial step in odorant detection. However, ligands have been reported for only 6 out of 380 human olfactory receptors, with their structural determinants of odorant recognition just beginning to emerge. Guided by the notion that amino acid positions that interact with specific odorants would be conserved in orthologs, but variable in paralogs, and based on the prediction of a set of 22 of such amino acid positions, we… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

Similar Papers

Loading similar papers…