Structural determinants of fast desensitization and desensitization-deactivation coupling in GABAa receptors.

@article{Bianchi2001StructuralDO,
  title={Structural determinants of fast desensitization and desensitization-deactivation coupling in GABAa receptors.},
  author={Matt T. Bianchi and Kevin F. Haas and Robert L Macdonald},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 4},
  pages={
          1127-36
        }
}
Fast IPSCs in the brain are predominantly caused by presynaptic release of GABA that activates GABA(A) receptor (GABA(A)R) channels. The IPSCs are shaped by the gating and desensitization properties of postsynaptic GABA(A)Rs. Specifically, fast desensitization has been suggested to decrease IPSC amplitude and to increase IPSC duration by slowing deactivation; however, the mechanisms underlying desensitization, deactivation, and their coupling are poorly understood. Consistent with this… CONTINUE READING

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GABAC receptor

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