Structural determinants of drug partitioning in surrogates of phosphatidylcholine bilayer strata.

Abstract

The knowledge of drug concentrations in bilayer headgroups, core, and at the interface between them is a prerequisite for quantitative modeling of drug interactions with many membrane-bound transporters, metabolizing enzymes and receptors, which have the binding sites located in the bilayer. This knowledge also helps understand the rates of trans-bilayer… (More)
DOI: 10.1021/mp400204y

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Cite this paper

@article{Lukacova2013StructuralDO, title={Structural determinants of drug partitioning in surrogates of phosphatidylcholine bilayer strata.}, author={Viera Lukacova and Senthil Natesan and Ming Peng and Roman Tandlich and Zhanbin Wang and Sandra Lynch and Rajesh Subramaniam and Stefan Balaz}, journal={Molecular pharmaceutics}, year={2013}, volume={10 10}, pages={3684-96} }