Structural determinants of drug partitioning in surrogates of phosphatidylcholine bilayer strata.

@article{Lukacova2013StructuralDO,
  title={Structural determinants of drug partitioning in surrogates of phosphatidylcholine bilayer strata.},
  author={Viera Lukacova and Senthil Natesan and Ming Peng and Roman Tandlich and Zhanbin Wang and Sandra Lynch and Rajesh Subramaniam and Stefan Balaz},
  journal={Molecular pharmaceutics},
  year={2013},
  volume={12 4},
  pages={1330-4}
}
The knowledge of drug concentrations in bilayer headgroups, core, and at the interface between them is a prerequisite for quantitative modeling of drug interactions with many membrane-bound transporters, metabolizing enzymes and receptors, which have the binding sites located in the bilayer. This knowledge also helps understand the rates of trans-bilayer… CONTINUE READING