Structural determinants of binding and specificity in transforming growth factor-receptor interactions.

@article{Shah2001StructuralDO,
  title={Structural determinants of binding and specificity in transforming growth factor-receptor interactions.},
  author={Purvi K Shah and Cristina Marino Buslje and R. Sowdhamini},
  journal={Proteins},
  year={2001},
  volume={45 4},
  pages={408-20}
}
Transforming growth factor (TGF-beta) protein families are cytokines that occur as a large number of homologous proteins. Three major subgroups of these proteins with marked specificities for their receptors have been found-TGF-beta, activin/inhibin, and bone morphogenic protein. Although structural information is available for some members of the TGF-beta family of ligands and receptors, very little is known about the way these growth factors interact with the extracellular domains of their… CONTINUE READING
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