Structural determinants of antimicrobial activity in polymers which mimic host defense peptides

@article{Palermo2010StructuralDO,
  title={Structural determinants of antimicrobial activity in polymers which mimic host defense peptides},
  author={Edmund F Palermo and Kenichi Kuroda},
  journal={Applied Microbiology and Biotechnology},
  year={2010},
  volume={87},
  pages={1605-1615}
}
Antimicrobial polymers, designed to mimic the salient structural features of host defense peptides, are an emerging class of materials with potential for applications to combat infectious disease. Because the putative mode of action relies on physiochemical parameters of peptides such as hydrophobicity and cationic charge, rather than specific receptor-mediated interactions, the activity of the polymers can be modulated by tuning key structural parameters. While a wide diversity of chemical… CONTINUE READING

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