Structural determinants of adenophostin A activity at inositol trisphosphate receptors.

@article{Corra2001StructuralDO,
  title={Structural determinants of adenophostin A activity at inositol trisphosphate receptors.},
  author={V. Corr{\^e}a and A. Riley and S. Shuto and G. Horne and E. P. Nerou and R. D. Marwood and B. Potter and C. Taylor},
  journal={Molecular pharmacology},
  year={2001},
  volume={59 5},
  pages={
          1206-15
        }
}
  • V. Corrêa, A. Riley, +5 authors C. Taylor
  • Published 2001
  • Chemistry, Medicine
  • Molecular pharmacology
  • Adenophostin A is the most potent known agonist of inositol 1,4,5-trisphosphate (InsP(3)) receptors. Ca(2+) release from permeabilized hepatocytes was 9.9 +/- 1.6-fold more sensitive to adenophostin A (EC(50), 14.7 +/- 2.4 nM) than to InsP(3) (145 +/- 10 nM), consistent with the greater affinity of adenophostin A for hepatic InsP(3) receptors (K(d) = 0.48 +/- 0.06 and 3.09 +/- 0.33 nM, respectively). Here, we systematically modify the structures of the glucose, ribose, and adenine moieties of… CONTINUE READING
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    References

    SHOWING 1-10 OF 51 REFERENCES
    Acyclophostin: a ribose-modified analog of adenophostin A with high affinity for inositol 1,4,5-trisphosphate receptors and pH-dependent efficacy.
    • 19
    • PDF
    Molecular recognition of adenophostin, a very potent Ca2+ inducer, at the D-myo-inositol 1,4,5-trisphosphate receptor.
    • 30
    Selective recognition of inositol phosphates by subtypes of the inositol trisphosphate receptor.
    • 43
    Inframolecular studies of the protonation of adenophostin A: comparison with 1-D-myo-inositol 1,4,5-trisphosphate.
    • 15
    Structure and function of inositol triphosphate receptors
    • 117
    Inositol 1,4,5-trisphosphorothioate, a stable analogue of inositol trisphosphate which mobilizes intracellular calcium.
    • 54
    Adenophostins, newly discovered metabolites of Penicillium brevicompactum, act as potent agonists of the inositol 1,4,5-trisphosphate receptor.
    • 177
    • Highly Influential
    Structure and function of inositol trisphosphate receptors.
    • 41