• DOI:10.1124/MOL.59.5.1206
Corpus ID: 26333907

Structural determinants of adenophostin A activity at inositol trisphosphate receptors.

@article{Corra2001StructuralDO,
  title={Structural determinants of adenophostin A activity at inositol trisphosphate receptors.},
  author={V. Corr{\^e}a and A. Riley and S. Shuto and G. Horne and E. P. Nerou and R. D. Marwood and B. Potter and C. Taylor},
  journal={Molecular pharmacology},
  year={2001},
  volume={59 5},
  pages={
          1206-15
        }
}

V. Corrêa, A. Riley, +5 authors C. Taylor

Published 2001

Chemistry, Medicine

Molecular pharmacology

Adenophostin A is the most potent known agonist of inositol 1,4,5-trisphosphate (InsP(3)) receptors. Ca(2+) release from permeabilized hepatocytes was 9.9 +/- 1.6-fold more sensitive to adenophostin A (EC(50), 14.7 +/- 2.4 nM) than to InsP(3) (145 +/- 10 nM), consistent with the greater affinity of adenophostin A for hepatic InsP(3) receptors (K(d) = 0.48 +/- 0.06 and 3.09 +/- 0.33 nM, respectively). Here, we systematically modify the structures of the glucose, ribose, and adenine moieties of… CONTINUE READING

View PDF

Save to Library

Create Alert

Cite

Launch Research Feed