Structural determinants of MscL gating studied by molecular dynamics simulations.

@article{Gullingsrud2001StructuralDO,
  title={Structural determinants of MscL gating studied by molecular dynamics simulations.},
  author={Justin R. Gullingsrud and Dorina Kosztin and Klaus Schulten},
  journal={Biophysical journal},
  year={2001},
  volume={80 5},
  pages={2074-81}
}
The mechanosensitive channel of large conductance (MscL) in prokaryotes plays a crucial role in exocytosis as well as in the response to osmotic downshock. The channel can be gated by tension in the membrane bilayer. The determination of functionally important residues in MscL, patch-clamp studies of pressure-conductance relationships, and the recently elucidated crystal structure of MscL from Mycobacterium tuberculosis have guided the search for the mechanism of MscL gating. Here, we present a… CONTINUE READING

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