Structural determinants of DNA recognition by plant MADS-domain transcription factors

@inproceedings{Muio2014StructuralDO,
  title={Structural determinants of DNA recognition by plant MADS-domain transcription factors},
  author={Jose M. Mui{\~n}o and Cezary Smaczniak and Gerco C. Angenent and Kerstin Kaufmann and Aalt D J van Dijk},
  booktitle={Nucleic acids research},
  year={2014}
}
Plant MADS-domain transcription factors act as key regulators of many developmental processes. Despite the wealth of information that exists about these factors, the mechanisms by which they recognize their cognate DNA-binding site, called CArG-box (consensus CCW6GG), and how different MADS-domain proteins achieve DNA-binding specificity, are still largely unknown. We used information from in vivo ChIP-seq experiments, in vitro DNA-binding data and evolutionary conservation to address these… CONTINUE READING
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