Structural determinants involved in the formation and activation of G protein betagamma dimers.

@article{McIntire2009StructuralDI,
  title={Structural determinants involved in the formation and activation of G protein betagamma dimers.},
  author={W. McIntire},
  journal={Neuro-Signals},
  year={2009},
  volume={17 1},
  pages={82-99}
}
Heterotrimeric G proteins, composed of an alpha, beta and gamma subunit, represent one of the most important and dynamic families of signaling proteins. As a testament to the significance of G protein signaling, the hundreds of seven-transmembrane-spanning receptors that interact with G proteins are estimated to occupy 1-2% of the human genome. This broad diversity of receptors is echoed in the number of potential heterotrimer combinations that can arise from the 23 alpha subunit, 7 beta… CONTINUE READING