Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures.

Abstract

Several autophagy proteins contain an LC3-interacting region (LIR) responsible for their interaction with Atg8 homolog proteins. Here, we show that ALFY binds selectively to LC3C and the GABARAPs through a LIR in its WD40 domain. Binding of ALFY to GABARAP is indispensable for its recruitment to LC3B-positive structures and, thus, for the clearance of… (More)
DOI: 10.1002/embr.201338003

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Cite this paper

@article{Lystad2014StructuralDI, title={Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures.}, author={Alf H{\aa}kon Lystad and Yoshinobu Ichimura and Kenji Takagi and Yinjie Yang and Serhiy Pankiv and Yumi Kanegae and Shun Kageyama and Mariko Suzuki and Izumu Saito and Tsunehiro Mizushima and M. Asaliaru Komatsu and Anne Simonsen}, journal={EMBO reports}, year={2014}, volume={15 5}, pages={557-65} }