Structural determinants for transport across the intestinal bile acid transporter using C-24 bile acid conjugates.

Abstract

The human apical sodium dependent bile acid transporter (hASBT) reabsorbs gram quantities of bile acid daily and is a potential prodrug target to increase oral drug absorption. In the absence of a high resolution hASBT crystal structure, 3D-QSAR modeling may prove beneficial in designing prodrug targets to hASBT. The objective was to derive a… (More)
DOI: 10.1021/mp100233v

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