Structural determinants for signal sequence function in the mammalian endoplasmic reticulum.

@article{Zheng1999StructuralDF,
  title={Structural determinants for signal sequence function in the mammalian endoplasmic reticulum.},
  author={Tianli Zheng and Christopher V Nicchitta},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 51},
  pages={36623-30}
}
Signal sequences function in protein targeting to and translocation across the endoplasmic reticulum membrane. To investigate the structural requirements for signal sequence function, chimeras of the Escherichia coli LamB signal peptide and prolactin were prepared. The LamB signal peptide was chosen by virtue of the extensive biophysical and biological characterization of its activity. In vitro, nascent prolactin chains bearing the LamB signal peptide (LamB) were targeted in a signal… CONTINUE READING

References

Publications referenced by this paper.

Signal Sequence Function in Translocation 36630 at D ke U nivrsity, on N ovem er 9, 2009 w w w .jb.org D ow nladed fom

W. M. Bonner, R. A. Laskey
Eur. J. Biochem • 1974

Similar Papers

Loading similar papers…