Structural determinants for HIV-1 integrase inhibition by beta-diketo acids.

Abstract

Among all the HIV-1 integrase inhibitors, the beta-diketo acids (DKAs) represent a major lead in anti-HIV-1 integrase drug design. These derivatives inhibit the integration reaction in vitro with a strong specificity for the 3'-end joining step. They are also antiviral and inhibit integration in vivo. The aim of the present study has been to investigate the… (More)

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Cite this paper

@article{Marchand2002StructuralDF, title={Structural determinants for HIV-1 integrase inhibition by beta-diketo acids.}, author={Christophe Marchand and Xuechun Zhang and Godwin C G Pais and Kiriana K. Cowansage and Nouri Neamati and Terrence R. Burke and Yves Pommier}, journal={The Journal of biological chemistry}, year={2002}, volume={277 15}, pages={12596-603} }