Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator.

@article{Khatri2014StructuralDA,
  title={Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator.},
  author={Alpa Khatri and Pieter B. Burger and Sharon A Swanger and Kasper B Hansen and S. Scott Zimmerman and Erkan Karakas and Dennis C Liotta and Hiro Furukawa and James P. Snyder and Stephen F Traynelis},
  journal={Molecular pharmacology},
  year={2014},
  volume={86 5},
  pages={548-60}
}
NMDA receptors are tetrameric complexes of GluN1, GluN2A-D, and GluN3A-B subunits and are involved in normal brain function and neurologic disorders. We identified a novel class of stereoselective pyrrolidinone (PYD) positive allosteric modulators for GluN2C-containing NMDA receptors, exemplified by methyl 4-(3-acetyl-4-hydroxy-1-[2-(2-methyl-1H-indol-3-yl… CONTINUE READING