Structural determinants and mechanism of HIV-1 genome packaging.

@article{Lu2011StructuralDA,
  title={Structural determinants and mechanism of HIV-1 genome packaging.},
  author={Kun Lu and X. Heng and M. Summers},
  journal={Journal of molecular biology},
  year={2011},
  volume={410 4},
  pages={
          609-33
        }
}
Like all retroviruses, the human immunodeficiency virus selectively packages two copies of its unspliced RNA genome, both of which are utilized for strand-transfer-mediated recombination during reverse transcription-a process that enables rapid evolution under environmental and chemotherapeutic pressures. The viral RNA appears to be selected for packaging as a dimer, and there is evidence that dimerization and packaging are mechanistically coupled. Both processes are mediated by interactions… Expand
New Structure Sheds Light on Selective HIV-1 Genomic RNA Packaging
Structural Dynamics of Retroviral Genome and the Packaging
HIV-1 leader RNA dimeric interface revealed by NMR
Identification of the initial nucleocapsid recognition element in the HIV-1 RNA packaging signal
Structure of the HIV-1 RNA packaging signal
Conserved determinants of lentiviral genome dimerization
Transcriptional start site heterogeneity modulates the structure and function of the HIV-1 genome
Identification of a minimal region of the HIV-1 5'-leader required for RNA dimerization, NC binding, and packaging.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 288 REFERENCES
Structural basis for packaging the dimeric genome of Moloney murine leukaemia virus
RNA Structure and Packaging Signals in the 5′ Leader Region of the Human Immunodeficiency Virus Type 1 Genome
...
1
2
3
4
5
...