Structural determinants and biophysical properties of HERG and KCNQ1 channel gating.

@article{TristaniFirouzi2003StructuralDA,
  title={Structural determinants and biophysical properties of HERG and KCNQ1 channel gating.},
  author={Martin Tristani-Firouzi and Michael C Sanguinetti},
  journal={Journal of molecular and cellular cardiology},
  year={2003},
  volume={35 1},
  pages={27-35}
}
The delayed rectifier K(+) currents, I(Kr) and I(Ks,) play a critical role in modulating the plateau phase of the cardiac action potential. HERG encodes the alpha-subunit of channels underlying I(Kr), while I(Ks) is composed of subunits encoded by KCNQ1 and KCNE1. Mutations in any of these genes cause the long QT syndrome, a disorder of myocellular repolarization that predisposes affected individuals to life-threatening arrhythmias. Elucidation of the molecular basis of these currents has led… CONTINUE READING