Structural definition of an antibody-dependent cellular cytotoxicity response implicated in reduced risk for HIV-1 infection.

@article{Acharya2014StructuralDO,
  title={Structural definition of an antibody-dependent cellular cytotoxicity response implicated in reduced risk for HIV-1 infection.},
  author={Priyamvada Acharya and William David Tolbert and Neelakshi Gohain and Xueji Wu and Lei Yu and Tongyun Liu and Wensheng Huang and Chih-chin Huang and Young Do Kwon and Robert K. Louder and Timothy S. Luongo and Jason S McLellan and Marie Pancera and Yongping Yang and Baoshan Zhang and Robin Flinko and James S. Foulke and Mohammad Mohseni Sajadi and Roberta Kamin-Lewis and James E Robinson and Lo{\"i}c Martin and Peter D. Kwong and Yongjun Guan and Anthony L. Devico and George K. Lewis and Marzena Pazgier},
  journal={Journal of virology},
  year={2014},
  volume={88 21},
  pages={
          12895-906
        }
}
UNLABELLED The RV144 vaccine trial implicated epitopes in the C1 region of gp120 (A32-like epitopes) as targets of potentially protective antibody-dependent cellular cytotoxicity (ADCC) responses. A32-like epitopes are highly immunogenic, as infected or vaccinated individuals frequently produce antibodies specific for these determinants. Antibody titers, as measured by enzyme-linked immunosorbent assay (ELISA) against these epitopes, however, do not consistently correlate with protection. Here… CONTINUE READING

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