Structural coupling of the inhibitory regions flanking the ETS domain of murine Ets-1.

@article{Skalicky1996StructuralCO,
  title={Structural coupling of the inhibitory regions flanking the ETS domain of murine Ets-1.},
  author={Jack J. Skalicky and Logan W Donaldson and Juanita M Petersen and Barbara J. Graves and Lawrence P. McIntosh},
  journal={Protein science : a publication of the Protein Society},
  year={1996},
  volume={5 2},
  pages={296-309}
}
Several members of the ets gene family of transcription factors show negative regulation of DNA binding by intramolecular interactions. A structural mechanism for this auto-inhibition is investigated using a 161-residue N-terminal deletion mutant of murine Ets-1, Ets-1 delta N280. This protein shows a similar reduced affinity for DNA as native Ets-1 because it contains the ETS domain in context of the flanking amino- and carboxy-terminal regions that together mediate repression of DNA binding… CONTINUE READING