Structural correlation between the nerve fiber layer and retinal ganglion cell loss in mice with targeted disruption of the Brn3b gene.

@article{Camp2011StructuralCB,
  title={Structural correlation between the nerve fiber layer and retinal ganglion cell loss in mice with targeted disruption of the Brn3b gene.},
  author={Andrew S Camp and Marco Ruggeri and Gustavo Costa Munguba and Mary L. Tapia and Simon W. M. John and Sanjoy K Bhattacharya and Richard Lee},
  journal={Investigative ophthalmology & visual science},
  year={2011},
  volume={52 8},
  pages={5226-32}
}
PURPOSE Mice with a targeted disruption of Brn3b (knockout Brn3b(-/-)) undergo the loss of a majority of retinal ganglion cells (RGCs) before birth. Spectral domain optical coherence tomography (SD-OCT) allows for the noninvasive examination of Brn3b(-/-) cellular loss in vivo. METHODS The central retinas of Brn3b(-/-) and phenotypically wild-type (Brn3b(+/+) and Brn3b(±)) mice were imaged by SD-OCT. The combined nerve fiber layer (NFL) and inner plexiform layer (IPL) were manually segmented… CONTINUE READING

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