Structural constraints and emergence of sequence patterns in protein evolution.

@article{Parisi2001StructuralCA,
  title={Structural constraints and emergence of sequence patterns in protein evolution.},
  author={Gustavo D. Parisi and Julian Echave},
  journal={Molecular biology and evolution},
  year={2001},
  volume={18 5},
  pages={
          750-6
        }
}
The aim of this work was to study the relationship between structure conservation and sequence divergence in protein evolution. To this end, we developed a model of structurally constrained protein evolution (SCPE) in which trial sequences, generated by random mutations at gene level, are selected against departure from a reference three-dimensional structure. Since at the mutational level SCPE is completely unbiased, any emergent sequence pattern will be due exclusively to structural… 
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