• DOI:10.1055/S-2006-959465
• Corpus ID: 33575154

Structural considerations on the iridoids as anti-inflammatory agents.

@article{Recio1994StructuralCO,
  title={Structural considerations on the iridoids as anti-inflammatory agents.},
  author={Mar{\'i}a del Carmen Recio and Rosa Mar{\'i}a Giner and Salvador M{\'a}{\~n}ez and Jos{\'e} Luis R{\'i}os},
  journal={Planta medica},
  year={1994},
  volume={60 3},
  pages={
          232-4
        }
}

• M. Recio, R. Giner, +1 author J. Ríos
• Published 1 June 1994
• Chemistry
• Planta medica

Twelve iridoid glycosides have been evaluated for their anti-inflammatory activity on two models: the carrageenan-induced mouse paw edema and the TPA-induced mouse ear edema. Loganic acid was the most active (44.4% edema inhibition) on the former test, whereas the catalpol derivative mixture isolated from Scrophularia, aucubin, verbenalin, and loganin, showed the highest activity (from 72.0 to 80.0% edema inhibition) on the latter. The results allowed us to establish the relationship between the structure and anti-inflammatory activity on the basis of the different patterns of substitution, particularly hydroxylation, unsaturation, and acylation.