Structural conservation in prokaryotic and eukaryotic potassium channels.

  title={Structural conservation in prokaryotic and eukaryotic potassium channels.},
  author={R. MacKinnon and S. L. Cohen and Anling Kuo and A. Lee and B. Chait},
  volume={280 5360},
  • R. MacKinnon, S. L. Cohen, +2 authors B. Chait
  • Published 1998
  • Biology, Medicine
  • Science
  • Toxins from scorpion venom interact with potassium channels. Resin-attached, mutant K+ channels from Streptomyces lividans were used to screen venom from Leiurus quinquestriatus hebraeus, and the toxins that interacted with the channel were rapidly identified by mass spectrometry. One of the toxins, agitoxin2, was further studied by mutagenesis and radioligand binding. The results show that a prokaryotic K+ channel has the same pore structure as eukaryotic K+ channels. This structural… CONTINUE READING
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