Structural conservation in prokaryotic and eukaryotic potassium channels.

@article{MacKinnon1998StructuralCI,
  title={Structural conservation in prokaryotic and eukaryotic potassium channels.},
  author={R. MacKinnon and S. L. Cohen and Anling Kuo and A. Lee and B. Chait},
  journal={Science},
  year={1998},
  volume={280 5360},
  pages={
          106-9
        }
}
  • R. MacKinnon, S. L. Cohen, +2 authors B. Chait
  • Published 1998
  • Biology, Medicine
  • Science
    • Toxins from scorpion venom interact with potassium channels. Resin-attached, mutant K+ channels from Streptomyces lividans were used to screen venom from Leiurus quinquestriatus hebraeus, and the toxins that interacted with the channel were rapidly identified by mass spectrometry. One of the toxins, agitoxin2, was further studied by mutagenesis and radioligand binding. The results show that a prokaryotic K+ channel has the same pore structure as eukaryotic K+ channels. This structural… CONTINUE READING
    View PDF
    369 Citations
    Highly Influential Citations
    10
    Background Citations
    110
    Methods Citations
    10
    Results Citations
    11

    Topics from this paper

    Explore Further: Topics Discussed in This Paper

    369 Citations
    Citation Type

    Citation Type

    Novel interactions between K+ channels and scorpion toxins.
    • 140
    Comparison of sea anemone and scorpion toxins binding to Kv1 channels: an example of convergent evolution.
    • 31
    Diversity of Potassium Channel Ligands: Focus on Scorpion Toxins
    • 41
    • PDF
    Structural determinants of scorpion toxin affinity: the charybdotoxin (alpha-KTX) family of K(+)-channel blocking peptides.
    • 34
    Potassium channel blockers from the venom of the Brazilian scorpion Tityus serrulatus ().
    • 9
    Active Sites of Spinoxin, a Potassium Channel Scorpion Toxin, Elucidated by Systematic Alanine Scanning.
    • 5
    • PDF
    A bifunctional sea anemone peptide with Kunitz type protease and potassium channel inhibiting properties.
    • 84
    • PDF
    Discovery and characterisation of a novel toxin from Dendroaspis angusticeps, named Tx7335, that activates the potassium channel KcsA
    • 10
    • PDF
    Evolutionary trace analysis of scorpion toxins specific for K‐channels
    • 32
    Molecular Diversity and Functional Evolution of Scorpion Potassium Channel Toxins*
    • 45
    • PDF

    References

    SHOWING 1-10 OF 19 REFERENCES
    Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom.
    • 235
    • PDF
    Agitoxin Footprinting the Shaker Potassium Channel Pore
    • 144
    The charybdotoxin family of K+ channel-blocking peptides
    • 293
    • PDF
    A Strongly Interacting Pair of Residues on the Contact Surface of Charybdotoxin and a Shaker K+ Channel
    • 126
    Interaction of charybdotoxin with permeant ions inside the pore of a K+ channel
    • 158
    Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor.
    • 406
    The structure of the potassium channel: molecular basis of K+ conduction and selectivity.
    • 5,750
    • PDF
    The charybdotoxin receptor of a Shaker K+ channel: Peptide and channel residues mediating molecular recognition
    • 261
    NMR sequential assignments and solution structure of chlorotoxin, a small scorpion toxin that blocks chloride channels.
    • 132
    • PDF
    Determination of the subunit stoichiometry of a voltage-activated potassium channel
    • 867