Structural comparison of mouse and human α-synuclein amyloid fibrils by solid-state NMR.


Fibrillar α-synuclein (AS) is the major component of Lewy bodies, the pathological hallmark of Parkinson's disease. Mouse AS (mAS) aggregates much faster than human AS (hAS), although mAS differs from hAS at only seven positions in its primary sequence. Currently, little is known about the site-specific structural differences between mAS and hAS fibrils… (More)
DOI: 10.1016/j.jmb.2012.04.009


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