Structural characterization of the antimicrobial peptide pleurocidin from winter flounder.

@article{Syvitski2005StructuralCO,
  title={Structural characterization of the antimicrobial peptide pleurocidin from winter flounder.},
  author={Raymond T. Syvitski and Ian Burton and Neil R. Mattatall and Susan E. Douglas and David L Jakeman},
  journal={Biochemistry},
  year={2005},
  volume={44 19},
  pages={7282-93}
}
Pleurocidin is an antimicrobial peptide that was isolated from the mucus membranes of winter flounder (Pseudopleuronectes americanus) and contributes to the initial stages of defense against bacterial infection. From NMR structural studies with the uniformly (15)N-labeled peptide, a structure of pleurocidin was determined to be in a random coil conformation in aqueous solution whereas it assumes an alpha-helical structure in TFE and in dodecylphosphocholine (DPC) micelles. From (15)N relaxation… CONTINUE READING

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